Monday, April 13, 2009
Becoming an Egg Donor
Donors may be anonymous or they may be known. Anonymous donors are recruited from local communities, are carefully screened, and their identities remain anonymous throughout the entire donor process. Known donors may be a family member, relative, or friend of the recipient.
Monday, April 6, 2009
Making the Right Choices When it Comes to Multiples
The recent birth of octuplets to a California woman receiving infertility treatment has raised questions about the practices used by infertility doctors. Dr. Pasquale Patrizio, director of the Yale Fertility Center, discusses the safeguards in place to ensure that nothing similar happens here.
Q. What is your reaction when you hear a story like the one about the woman in California giving birth to octuplets?
A. I am not happy. High order multiple births (triplets or more) resulting from in vitro fertilization (IVF) are considered medical failures. Besides the known pregnancy complications of multiple births—preterm labor and the many health concerns related to premature delivery—there is also the issue of how are you going to raise these children. If someone comes to me and already has six children, like in this particular case, I have a duty to refer this patient to social service. If she’s asking me to transfer eight embryos, something is not right.
Q. IVF treatments can cost $10,000 a piece. What do you do if a patient comes to you and says, “I don’t’ have a lot of money for IVF treatments. Could you please implant as many embryos as possible to improve my chances of getting pregnant on the first try?”
A. We have to follow the guidelines developed by the American Society of Reproductive Medicine. It’s simply not okay to transfer six or seven embryos into a woman who is younger than 35 and has a good prognosis for a successful pregnancy. So, it doesn’t matter if the woman requests that I implant all the embryos. I’m not going to honor that request.
Q. What are the guidelines?
A. For a woman younger than 35 with a good prognosis, the guidelines say one embryo if the transfer is performed on day five after egg retrieval, with a maximum of two if the transfer is performed on day three. The older the woman, the more embryos we’re allowed to transfer. At 40, you can transfer three or four tops. For patients 42 or older, you can transfer up to 5. If someone goes beyond this, you really need a valid justification, and it’s very, very rare.
Q. But these are just guidelines, right? They’re not mandatory?
A. Right. We voluntarily file annual clinic summary reports with the Society of Assisted Reproductive Technologies (SART). The reporting rate is about 95 percent, so we’re doing a pretty good job of making our data available for public scrutiny and information.
Q. What do you report?
A. The age of the woman, the number of cycles started, the number of retrievals, the average number of embryos transferred by age group, the number of pregnancies, the number of deliveries, the number of multiple births and the number canceled cycles. Centers can also be audited, which is one way we protect citizens from cheaters. If a center makes up numbers and is caught, there can be sanctions.
Q. Would there be less pressure from patients to implant multiple embryos if insurance for infertility treatment were better?
A. It’s possible. In Belgium and some other European countries, insurance pays for treatment, and insurers tell you how many embryos you can implant. In the United States only 15 out of the 50 states [including Connecticut] mandate insurance coverage for infertility. Somebody should do a study on whether states that cover infertility have fewer multiple births than states that don’t.
Q. Does competition among centers add to the temptation to implant more embryos to keep the pregnancy success rate high?
A. There’s definitely pressure on centers to compete, and patients do their homework about clinic success rates. There are 425 fertility clinics in the United States, but the number of cycles of IVF has flattened, because the baby boomer generation is now older.
Q. Is the number of high order multiple births going down?
A. The number is indeed going down. The number of triplets is now around 2 percent. A few years ago it was 3.5 to 4 percent, and in 1996 it was 7 percent. The average number of embryo transfers has been decreasing, too, from an average of four in 1996 to 2.6 now.
Q. What about selective reduction (targeting one or more fetuses in a multifetal pregnancy for termination) as a way of avoiding multiple births?
A. We try not to go there, but since women are very well-informed about infertility treatments and procedures, sometimes they ask you, “Please implant three embryos. If they all survive, I’ll have a selective reduction.” I’m personally not very comfortable with this concept. I only want to use it as a last, last, last resort.
Q. Does an incident like the California octuplets undermine the credibility of your field?
A. Yes, of course. You see how much ink has been spent on this issue, and it makes us, as a professional group, look bad. There is so much hard work by a team of professionals behind the scenes to help couples achieve what is perhaps one of the most important reasons we are on the planet: to reproduce, to have offspring.
Q. With all that has been written about the octuplet case, has anything been lost in the debate?
A. What has been lost is the sacrifice, the hours and hours of work that have gone into creating a treatment for infertility that is successful and the incredible amount of joy we have been able to bring to families.
Q. Besides implanting more embryos, what else can be done to improve an infertile couple’s odds of having a baby?
A. Research is being done on identifying the best embryo to implant, trying to find markers of embryo implantation potential. We’re also looking at methods for identifying the best egg.
Q. How is that research going?
A. I predict that five years from now you’ll see many more single-embryo transfers. There has to be a coalition of events: technological advances, better insurance coverage, less competition among clinics, but I am convinced that in a few years, this is going to happen, and higher order pregnancies from IVF will be history.
—Jennifer Kaylin
Photo by Jennifer Kaylin
To find out more about the Society for Assisted Reproductive Technology or to view clinical survey reports from any center in the United States, go to www.sart.org.
Tuesday, March 24, 2009
The Octuplet Pregnancy
One way for the public to asses the quality and safety of an infertility practice is thorough examination of SART data. This is publicly available through the SART web site and from the Centers for Disease Control and Prevention (CDC). Pregnancy rate per cycle can be assessed as well as the number of multiple gestation pregnancies. While there is no category for octuplets on the SART form (as this may never have happened previously), the number of twins and triplets can be identified. Another telling figure is the average number of embryos transferred. SART specifies that this should be no more than two in young women with high quality embryos. While this number may reasonably be higher when age, embryo quality or prior failures are taken into account, it should be well under three on average. In the case of the octuplets these numbers suggest a practice that is well outside of the SART recommendations. In that California practice the average pregnancy rate was low and the number of embryos transferred was shockingly high.
As Clinical Director of SART, I can assure you that action is being taken to prevent future occurrences of higher order multiples. We do not want this episode to tarnish the reputation of the vast majority of our member clinics that practice responsible medicine. This case has highlighted the need to improve the quality assurance processes that SART has in place. We will be more vigilant in identifying unsafe situations in order to prevent these types of negative outcomes.
Starting with the most recent data released earlier this month, SART will identify outlier programs that are consistently not compliant with embryo transfer guidelines and have high order multiple pregnancies. SART will identify all cycles in which the number of embryos transferred in young patients exceed guidelines and will require an explanation for the guideline deviation. Programs that have consistently poor pregnancy outcomes will be offered assistance from SART to help them improve. If they do not respond or fail to demonstrate a real effort to reduce the number of embryos transferred, SART membership will be revoked.
At Yale we have a high pregnancy rate, the only program in our state to have a greater than 50% pregnancy rate in any age group. We do this with an average number of embryos transferred that is well less than three. I can assure you that patients at Yale are receiving high quality and safe IVF treatment from leaders in the field.
Wednesday, March 18, 2009
Vitamin D: Sunlight Can Be Good for You

Evidence is growing that Vitamin D is crucial to many aspects of health—and that deficiency is extremely common, even in seemingly healthy people. The vitamin’s best-known role is in building bone, but low levels also appear to be associated with diabetes, heart disease, and infertility, among other diseases. “When you start looking at the data, the health benefits of D appear to be at every cellular level, in multiple organs,” said Lubna Pal, M.B.B.S., director of the Reproductive Aging and Bone Health Program.
Pal and her colleagues studied the health records of over 400 healthy pre-menopausal women and found that an astonishing 79% of them had low vitamin D levels. She found a link between low vitamin D levels and abnormal levels of blood sugar, insulin, inflammatory markers, and body mass. Such markers are associated with a higher risk of cardiovascular disease and diabetes. Women who were not Caucasian had lower levels of vitamin D, while more physically active women had higher levels.
In a previous study, Pal checked levels of vitamin D in the ovaries of 84 women undergoing fertility treatments. Almost two-thirds of the women had low levels, and those who achieved pregnancy had, on the average, higher levels of vitamin D than those who didn’t.
Vitamin D is made by the skin when touched by sunlight; it is also found in some foods. “We’re becoming more under-the-shade workers [and are] not getting our daily allowance,” said Pal. She suggests spending 10 minutes in the sun each day.
Wednesday, February 18, 2009
Octuplets Case Sparks Ethics Uproar Over IVF Excess and Patient Screening Fertility groups want a closer look at the doctor's actions, but oppose more
What began in late January as a feel-good story of a California medical team's Herculean efforts to deliver octuplets after a 31-week pregnancy quickly morphed into a controversy over the medical ethics of fertility practices.
The octuplets' mother, 33-year-old Nadya Suleman, said in an interview on NBC's "Today" that her physician transferred six embryos and two split. Suleman is single, unemployed and has six other young children. All were conceived through in vitro fertilization at the same clinic, she said. For each pregnancy, her doctor transferred six embryos, Suleman said.
If that is true, the physician's actions went well beyond American Society for Reproductive Medicine guidelines, society president R. Dale McClure, MD, said in a statement. The Medical Board of California is investigating, and the ASRM has offered to aid the inquiry. The AMA referred requests for comment to the ASRM.
"What was done is clearly irresponsible, clearly unethical, and it placed the life and health of the mother as well as the fetuses at great risk," said Samuel H. Wood, MD, PhD, a La Jolla, Calif., reproductive endocrinologist. "It's simply the wrong thing to do."
For a woman younger than 35 with a previous successful IVF cycle, the ASRM recommends transferring one embryo -- two at most. The society says pregnancies with four fetuses or more pose huge risks, including a 95% chance of pre-term labor and delivery, and a greater than 60% chance of preeclampsia. One in 10 such pregnancies results in gestational diabetes mellitus.
Pasquale Patrizio, MD, director of the Yale Fertility Center in Connecticut, said he would not have transferred so many embryos in a patient "for any reason. I don't understand why such a decision was made. No matter how much a patient may insist on a transfer of such a large number of embryos, it is out of the question and the request should not be honored at all."
Suleman, who said she has occluded fallopian tubes, told "Today" she dreamed of having a "huge family" and her goal with this pregnancy was to have one more child. She refused to selectively reduce the embryos when she learned six had been implanted successfully.
As of early February, the eight low-birth-weight babies were being tube fed donated pasteurized breast milk and monitored in the Kaiser Permanente Medical Center in Bellflower, Calif., where they were born. The hospital said the babies were expected to remain for several more weeks.
Regulation the answer?
The fertility practice Suleman named in her interview, West Coast IVF Clinic Inc. in Beverly Hills, Calif., is a member of the Society for Assisted Reproductive Technology. SART is an ASRM affiliate that represents more than 85% of U.S. fertility clinics and describes itself as a "governmental watchdog for ART" with quality-assurance expertise.
SART has contacted the clinic's medical director, Michael M. Kamrava, MD,to learn more about the medical circumstances of the case before taking any action, which could include revoking the clinic's society membership. Dr. Kamrava, an ob-gyn who was shown treating Suleman in a 2006 Los Angeles TV news show, declined requests from AMNews for an interview.
The Suleman case shows the fertility industry's self-regulation is insufficient, said Debora L. Spar, PhD, author of The Baby Business: How Money, Science, and Politics Drive the Commerce of Conception, which examined the market for reproductive technology. She said government should set rules on how many embryos can be transferred.
"Most people are agreeing this was an extreme case," Spar said. "That is exactly what regulation is best suited for. It defines the extreme and unacceptable behavior. Even if you took the ASRM guidelines, I think what this case shows is that even reasonable guidelines are not necessarily followed by unreasonable practitioners, and it is those unreasonable practitioners that you have to worry about."
The California medical board's decision to investigate may not prevent similar cases, Spar said. "We don't want regulation after the fact. We want regulation beforehand."
Fertility doctors said the proportion of high-order multiple births has dropped, thanks to better methods of culturing embryos and ASRM guidelines on transfers. The percentage of IVF cycles resulting in triplets or more fell 69%, to 4.3%, from 1997 to 2005, the last year for which data are available from SART and the Centers for Disease Control and Prevention.
"This particular case is a big problem, but I don't think we have a big problem generally," said James A. Grifo, MD, PhD, program director of the New York University Fertility Center. He said regulation could have unintended consequences, contending that a 1992 law requiring the CDC to publicly track clinics' success rates perversely encouraged physicians to increase the number of embryos they transferred to improve the odds.
"We passed the guidelines and made recommendations for what doctors should do, adjusting for the fact that not all patients are the same," said Dr. Grifo, a past president of SART. "Medicine is not formulaic. If it were, then why do we need doctors? We should just go to a computer."
Screening patients
Others said the case -- Suleman now is the sole parent to 14 children younger than 8 -- highlighted the need for more screening of prospective parents seeking reproductive technology services.
"I would like to see a mandatory psychological evaluation," said Arthur L. Caplan, PhD, director of the University of Pennsylvania Center for Bioethics. Caplan noted that such screening is standard for living organ donors and patients seeking bariatric surgery. "We need to look at what steps we can take to ensure they will be competent parents."
The ASRM published guidelines in 2004 saying fertility clinics could "withhold services from prospective patients on the basis of well-substantiated judgments that those patients will be unable to provide or have others provide adequate child rearing for offspring." The guidelines do not call for routine screening or home studies.
Fertility specialist Dr. Wood said he has referred a number of prospective parents for psychological counseling. At the same time, some doctors fear trampling on their patients' autonomy.
"I don't feel comfortable being in a position to tell a couple, or a woman, 'You're not going to do any more, because you have enough kids,'" said Yale's Dr. Patrizio. "It's not morally correct because it's not my reproductive right; it's her reproductive right. If she wants to have a large family -- do it one at a time or, at the max, two at a time. But it's her choice."
Tuesday, January 13, 2009
Assisted Reproduction Options for Same-sex Couples
Greenfeld is the first person potential parents meet at YFC (except for those needing help only with insemination). She administers a psychological evaluation and gives them a detailed picture of what to expect from the long process of achieving parenthood. Part of her job is to ask the questions that potential parents may not have asked themselves.
For example, male couples often decide before going to YFC which of them will be the sperm donor. But Nature might not cooperate, and Greenfeld wants them to be prepared. “You might be very clear about who’s going to produce the sperm, but you might also be the guy who can’t produce the sperm,” she points out.
The Center works with couples to come up with individual solutions for their particular situation. Some seek simply an egg donor, a gestational surrogate to carry the pregnancy, or sperm. But more complex scenarios are possible. One lesbian couple at YFC achieved the “dream scenario,” in which one partner provided the egg and the other carried the pregnancy. And one pair of fathers had twins—one twin from each father’s sperm—with the help of a surrogate mother. Whatever arrangement is made, YFC requires that at least one potential parent be biologically connected to the child, providing either eggs, sperm, or womb.
Prejudices persist about gay parents, including fears that they will be less nurturing or that their children are less likely to marry, but these are subsiding amid recognition that gay couples make good parents. Greenfeld has written about the need to overcome such myths. “So many [gay] men have spent their life dreaming about being dads,” said Greenfeld, “and often say things like ‘I just didn’t think it would be possible.’” But the children of the proud gay and lesbian parents who conceived with YFC are proof that it is.
Tuesday, November 18, 2008
The Emotional Rollercoaster

“Emotional rollercoaster” is a phrase often used to describe the ups and downs of infertility. As if the diagnosis and the treatment weren't difficult enough, the emotional turmoil surrounding infertility—while perfectly normal—is yet another source of anxiety and stress. Psychological support and counseling can be very helpful to couples going through this process.
Although infertility affects one in six couples in the United States, when faced with it most people feel isolated and alone. Especially difficult but normal feelings associated with infertility are:
- A loss of interest in usual activities
- Difficulty thinking of anything other than one's infertility
- Change in sleeping and/or eating patterns
- Fleeting thoughts of death and dying
- Difficulty making decisions
- Feelings of isolation and loneliness
At times these symptoms may lead to strained relationships with one's partner, family, friends, and/or colleagues at work. An open (but entirely confidential) discussion of these issues with a counselor can often be quite helpful. In fact, infertile couples face a number of issues that can be helped by a meeting with a mental health professional.
A counselor can provide important information about treatment options and help to facilitate discussion of such highly charged topics as whether or not to pursue a particular treatment; whether and how to pursue third party assistance (such as donor sperm, donor oocyte, and surrogacy); and whether or not to pursue adoption. The counselor can also help with questions about multiple pregnancy, pregnancy loss, and when and whether to stop treatment.
- Dorothy A. Greenfeld, LCSW